Drugs Used To Treat Diabetes type 2

Treatment approach for type 2 diabetes
Approximately 80-90% of diabetics have obese type 2 diabetes and may be inadequate if non-medical measures such as diet-appropriate diabetes (“diet”) – especially to achieve weight loss – and exercise, are treated with blood sugar lowering tablets. Insulin dosage will be needed here at a later date.
Since type 2 diabetes is a “double” disease, i. There are two causes, namely, innate insulin resistance and insufficient beta-cell weakness for rapid insulin release can be resolved at both stages of disease progression.

diabetes_medikamente_neu_gut_und_wirklich_teuer@1x Drugs Used To Treat Diabetes type 2

In 2000, tablets were first approved in Germany, which directly increases insulin sensitivity of inherited body cells, i. break insulin resistance, On the other hand, in addition to the stimulating agent of insulin secretion that has been used so far, new drugs have been available that release insulin very quickly and for a short time.

Increased insulin sensitivity by so-called “insulin sensitizers”
On the one hand, the fundamental disorder of type 2 diabetes, insulin resistance, is congenital, on the other hand, it can be aggravated again during life with overweight and lack of exercise.
With the thiazolidinediones group, the substance is now available for the first time that penetrates insulin resistance. While the first substance, available in the US and in Japan, troglitazone, was withdrawn from the market due to a rare liver incident, now the “2nd generation” of this preparation group is also used in Germany, which does not create problems with the liver. The thiazolidinediones attack the nucleus of fat, muscle and liver cells in the nuclear receptor, the gamma “Peroxisome Proliferator-Activated Receptor (PPAR)”, and increase the reduced insulin signals. Among other things, protein molecules, called “glucose transporters” are increasingly being formed and brought to the surface of these cells, which then transport sugar from the bloodstream into interior cells. Blood sugar drops and body cells can return to normal function.

Preparations available in Germany since 2000 are Rosiglitazone (trade name Avandia, Glaxo SmithKline) and Pioglitazone (trade name Actos, Takeda). While both preparations are also approved in the US for the treatment of single diabetes, called monotherapy, this does not occur in Germany and Europe in the same way. They may be given in EU countries in addition, if with a sulphonylurea or with a metformin biguanide (see below) metabolism cannot be adequately adjusted or if there is contraindication or intolerance to metformin.

Combinations with US insulin may not be permitted in Germany because of the negative effects on cardiac output observed in the study.

Rapid stimulation of insulin release by Glinide
Another basic flaw in type 2 diabetes is the disruption of insulin secretion, initially especially in the early stages. This abnormality of insulin release can already be detected in hereditary person although there is no interruption of sugar metabolism.
Whereas previously, the stimulating substance of insulin secretion, sulfonylurea, usually acts longer, is now available a substance, called “Glinide”, which releases insulin rapidly and briefly, thereby reducing the rise in blood sugar after meals, which after new can severely damage blood vessels: this new “insulinotropic” does not contain chemical sulfonylureas.
The first product on the German market is Repaglinide, a benzoic acid derivative, the trade name NovoNorm, marketed by Novo Nordisk. Preparation should be done before meals at any time, then release the insulin in a short time and the effect immediately stops. This allows flexibility in eating foods. Whether or not you can eat, you just leave the tablet and there is a bit of hypoglycemia. In particular, nocturnal hypoglycemia in the form of this treatment decreases.
Since 2001, other drugs on the German market, which act much faster, nateglinide (trade names Starlix, Novartis, and Merck). It comes from the dextrorotatory amino acid, D-phenylalanine. Nateglinide is approved in combination with metformin biguanide (see below).

Preparations available before
Among the secretions of insulin-induced sulfonylureas, glimepiride (trade name Amaryl, Aventis company) are usually given only once a day. A slightly lower level of hypoglycemia has been reported, which has been reported more commonly with glibenclamide (trade names Euglucon (Aventis) and others) when used improperly. However, it does not mean that a person no longer uses older sulphonylurea preparations.
A “renaissance” is currently undergoing methanynamin of the biguanide drug, especially “UKPDS”, a long-term study in the UK that has produced excellent results in overweight type 2 diabetics in preventing heart attacks and other diabetes complications with metformin.
Finally, there are also Acarbose alpha-glucosidase inhibitors (trade names Glucobay, Bayer) and Miglitol (trade name Diastabol, Sanofi-Synthelabo) available, which is well tolerated by patients in the gastrointestinal tract, as well as reduction of blood sugar, especially peaks after meals, effects.

summary
Currently, we have more options for “customized” and differentiable therapies for type 2 diabetes.
In many cases, a combination of tablets will be necessary for oral therapy during the course of the disease. Absolutely not necessarily the use of insulin is delayed for too long. Combining more than two or in special cases three tablets brings little or no benefit.
As a rule of thumb, one can remember it: If the fasting blood sugar is above 120 mg/dl / 6.7 mmol / l and HbA1c above 7.0% or above the individual, it also depends on the target age value, then each should upgrade to the next therapeutic stage. which, in the case of prior use of two (or at most three) hypoglycemic tablets is a combination therapy of oral antidiabetes with insulin or single insulin therapy against conventionally modified insulin therapy with multiple insulin injections per day.

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Which Cereal Has The Least Sugar

The use of cereal grains has undergone great development over time. Starting with self-ground granular porridges and nutritious flatbreads up to the modern times with snow-white nutrient-free extractable flours.

ewg-low-sugar-cereal-list Which Cereal Has The Least Sugar

Healthy alternatives to white flour and Co., with which you can bake your low carb bread and cook great low carb recipes, we present to you now.

White flour goodbye – back to full grain
The white, very pure extract flour contains no valuable nutrients more. These are almost dead material. White flour and similar other pulp varieties are therefore completely out of place in the low carb diet. These flours deliver carbohydrates in high concentration and nothing else. Fortunately, there are healthier alternatives.

Because the grain industry has not escaped the change in diet. The trend comes from two directions: on the one hand, more and more people consciously feed on low carbohydrates, on the other hand, more and more in-depth information about the wheat flour penetrates to the public. Similar to sugar, traditional white flour is anything but healthy! Meanwhile, numerous studies show a connection between the one-sided permanent diet of white flour and arteriosclerosis, diabetes, rheumatism and heart disease.

With the increasing demand for a low carb diet line, more and more different types of flour are coming onto the market more and more. The white flour is due to various unpleasant side effects, including one hitherto hidden addictive behavior in combination with the weight gain.

Low carb flour in the supermarket
Only a little while ago it was almost impossible to buy low carb flour here in Germany. Today, several manufacturers are already offering good products. There are pure wholesome flours from grains other than wheat, such as. As spelled and so-called low carb flours, which consist to a large extent of a protein mixture and other ingredients. These include coconut flour, pea proteins, whey protein and psyllium husks.

Nevertheless, these flours may contain wheat fibers and thus the gluten or traces of peanuts which are incompatible with many people. Allergy sufferers should always pay attention to the individual ingredients when using the term protein bread.

Wholemeal flour – the best of the whole grain
The whole grain contains, as the name implies, the whole grain with its valuable fiber, vitamins, healthy fats, minerals and surface layers. In particular, the proportions of natural oil has a health-promoting effect with its high content of essential fatty acids.

Whole wheat flour saturates better and longer than extract flour. Due to the oils in the flour, it is not quite as durable. At that time, that was the real reason why industrially it began to eliminate the seedling from the flour grains – the durability. Wholemeal flours should, therefore, be consumed more quickly, to prevent them from becoming rancid and giving them an unpleasant taste. For our body, whole wheat flour is definitely the better choice.

Whole wheat flour can be eaten in small amounts in the low carb diet. Many wholemeal flours contain gluten. Depending on how sensitively the body reacts to gluten, you can enjoy small amounts of the quite tasty whole grain bread or other wholemeal dishes on a low carbohydrate diet.

Spelled flour is one of the much healthier flours because of its high content of minerals such as magnesium, potassium, iron and phosphorus. Spelled was frowned upon for a long time and today belongs to the rediscovered types of flour in the healthy and wholesome diet. Spelled does not have the same properties as wheat, its gluten content is higher, but the baking capacity is lower.

Try baking a cake with spelled flour 1050 (wholemeal flour). For some recipes, the final product is a bit flatter than white flour. Then you should add 10% more flour next time. Spelled flour is also excellent for cooking. Pasta made from spelled flour, casseroles and vegetable dishes are simply delicious.

People with gluten intolerance need to know that spelled contains gluten. Some people, however, tolerate spelled very well in small quantities.